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Females with high androgen levels may develop acne, facial hair and other issues.
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Cancerous adrenal tumors can be functional and release excess of one or more hormones accompanied by corresponding symptoms, as listed above.
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If serum dehydroepiandrosterone sulphate (DHEAS) is raised, it is presumed to be of adrenal origin because DHEAS is exclusively produced from adrenal cortical cells.
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The diagnosis of adrenal insufficiency (AI) requires a high index of suspicion, detailed clinical assessment including detailed drug history, and appropriate laboratory evaluation.